Ovarian rejuvenation with PRP: Testimonials & Costs in Turkey

What is ovarian rejuvenation therapy with PRP?

Ovarian rejuvenation with PRP (platelet-rich plasma) is an experimental technique. It uses components of your own blood. Growth factors in the plasma are thought to support the repair of ovarian tissue and may influence hormone production and egg development, but this has not been demonstrated in large trials.

It is performed as an outpatient procedure in three stages: blood collection, preparation of PRP in a laboratory, and injection into the ovarian tissue under ultrasound guidance. The technique is similar to the one used for egg retrieval (transvaginal, ultrasound-guided needle),but the PRP protocols (preparation, dose, injection method) are not standardized between clinics.

A specialist at a partner clinic can explain what is known, what is not, and whether this option makes sense for you.

Who can be considered for ovarian PRP?

PRP ovarian therapy administered through Turquie Santé's network is designed for women seeking to improve reproductive health and fertility through a natural approach.

Typical candidates

After a full assessment, PRP may be offered, within a supervised protocol and with realistic expectations, to women who:

• Have diminished ovarian reserve or low AMH, whether they hope to conceive naturally or through IVF.
• Have premature ovarian insufficiency (POI). Some small studies report an occasional return of ovulation, but the response is unpredictable.
• Are approaching or in early menopause. Evidence in this situation is very limited.
• Have poor response to ovarian stimulation in previous IVF cycles.
• Are in good general health, without active chronic conditions

Treatment is not suitable for every woman. Your doctor may advise against it, or recommend IVF directly, if your results suggest a low chance of benefit. If time is a factor, ask whether PRP could delay a treatment with stronger evidence.

Contraindications and situations requiring caution

PRP should not be performed in women with:

• Active or untreated pelvic inflammatory disease or other pelvic infection.
• Known or suspected ovarian or reproductive-tract cancer, or an ovarian mass that has not been evaluated.
• Blood disorders or autoimmune conditions affecting blood or platelet function, or treatment with blood thinners (never stop a prescribed treatment without medical advice).
• Current or suspected pregnancy, or breastfeeding.

Tell your doctor about ovarian cysts or endometriomas, allergies to anesthetics or antiseptics, previous pelvic surgery or infections, and all medications you take.

PRP ovarian rejuvenation process in Turkey

Treatment through Turquie Santé's partner clinics follows a structured yet flexible approach. Minimally invasive. Outpatient-friendly. Comfort-centered throughout.

1. Initial consultation and assessment: reproductive history, hormone tests, ovarian reserve testing and ultrasound. These results determine whether treatment can be considered.
2. Blood collection and PRP preparation: a blood sample is processed in sterile conditions to isolate the platelet-rich plasma, which usually takes 15–30 minutes.
3. PRP injection: the PRP is injected into the ovarian tissue by a transvaginal route under ultrasound guidance. Discomfort varies between women. Ask your doctor which anesthesia or sedation is used. You go home the same day.
4. Recovery and follow-up: light cramping is common. Follow-up ultrasounds and hormone tests are planned by your doctor, usually starting about 4–6 weeks after the injection and repeated over the following months.

Visual process maps or step-by-step infographics help demystify what happens at each stage, building patient confidence and engagement before treatment begins.

What is known about safety?

Intra-ovarian PRP has been used in small studies, and the evidence on safety is limited because the technique is recent and long-term follow-up is lacking. The following points are known:

• Own blood only: this removes the risk of transmitting infections from another person, but does not remove the risks of the procedure (see “Risks and side effects”).
• Same type of access as egg retrieval: ultrasound-guided transvaginal puncture is a well-known procedure, but its use for PRP injection is not standardized.
• Serious complications appear to be rare in the published reports, but their true frequency is not established. Rare cases of ovarian abscess have been reported.
• Long-term effects on ovarian function and future fertility have not been established.

The risk depends on the experience of the team and on your own medical situation, so discuss it in detail with your doctor.

Risks and side effects

PRP ovarian injection is an invasive procedure and, being experimental, its risks are not fully documented. Possible risks include:

• Bleeding, including ovarian hemorrhage (rare),and bruising or hematoma.
• Cramping and pelvic discomfort, usually mild to moderate.
• Infection, including pelvic infection and, rarely, ovarian abscess.
• Injury to nearby structures (bladder, bowel, blood vessels),which is rare with ultrasound-guided needle procedures.
• Inflammatory reaction in the treated tissue.
• Bruising, pain, or fainting related to the blood draw.
• Reactions to anesthesia or sedation, if used.
• Unknown long-term effects on ovarian tissue, hormone function, and future fertility, as no long-term data exist.
• No benefit at all: many women do not respond.

As with any invasive medical procedure, unexpected reactions can occur that have not yet been described for this therapy. Because the plasma comes from your own blood, the risk of transmitting infections from a donor is removed, but the procedure itself still carries risks. Ask your doctor about the anesthesia used, the clinic's emergency procedure, and how complications are managed (complication management).

What results can you expect?

No result can be promised. Studies report variable outcomes, and many women do not respond. Changes in hormone levels or cycles, when they occur, may appear within weeks to months. Some women see changes within about 3 months, others only after 6–12 months, and many see none.

Findings reported in some studies, mostly small, observational or without control groups:

• Ovarian reserve markers: increases in antral follicle count (AFC) or AMH in some studies
• Menstrual cycle: return of regular cycles in some patients
• IVF response: better ovarian response or more eggs retrieved in some women who went on to IVF
• Menopause symptoms: relief or a longer reproductive window reported in limited case series, which is not an established effect

Individual results depend on age, baseline ovarian reserve and general health. Long-term efficacy data remain limited, and treatment is best offered within structured clinical protocols with regular monitoring.

Recovery process

Most women go home the same day.

• Cramping, similar to mild period pain, usually eases within hours to 48 hours.
• Light activity can resume within 24–48 hours, normal work and routines within 1–3 days, and strenuous exercise after about one week.
• Follow your doctor's instructions on medication, intercourse and activity restrictions.

Contact the clinic or a doctor promptly if you have:

• Fever of 38 °C (100.4 °F) or higher.
• Severe or worsening pelvic pain, or pain not relieved by usual painkillers.
• Heavy vaginal bleeding (for example, soaking a pad every hour).
• Foul-smelling or unusual discharge.
• Dizziness or fainting.

If you are traveling for treatment:

• Ask whether you should stay in Istanbul for the first 24-48 hours.
• Keep the clinic's emergency contact with you, and check what your travel insurance covers.
• Ask in writing when and how your test results will be sent to you, and ask for your medical documents in English.
• Share these documents with your own doctor and arrange local follow-up tests if needed.